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Báo cáo khoa học: " Proteomics computational analyses suggest that the bornavirus glycoprotein is a class III viral fusion protein (γ penetrene)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Proteomics computational analyses suggest that the bornavirus glycoprotein is a class III viral fusion protein (γ penetrene)b | Virology Journal BioMed Central Research Proteomics computational analyses suggest that the bornavirus glycoprotein is a class III viral fusion protein y penetrene Courtney E Garry and Robert F Garry Open Access Address Department of Microbiology and Immunology Tulane University Heath Sciences Center New Orleans Louisiana 70112 USA Email Courtney E Garry - cgarry@gmail.com Robert F Garry-rfgarry@tulane.edu Corresponding author Published 18 September 2009 Received 13 August 2009 Accepted 18 September 2009 Virologyjournal 2009 6 145 doi l0.ll86 l743-422X-6-l45 This article is available from http www.virologyj.cOm content 6 l l45 2009 Garry and Garry licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Borna disease virus BDV is the type member of the Bornaviridae a family of viruses that induce often fatal neurological diseases in horses sheep and other animals and have been proposed to have roles in certain psychiatric diseases of humans. The BDV glycoprotein G is an extensively glycosylated protein that migrates with an apparent molecular mass of 84 000 to 94 000 kilodaltons kDa . BDV G is post-translationally cleaved by the cellular subtilisin-like protease furin into two subunits a 4l kDa amino terminal protein GPl and a 43 kDa carboxyl terminal protein GP2. Results Class III viral fusion proteins VFP encoded by members of the Rhabdoviridae Herpesviridae and Baculoviridae have an internal fusion domain comprised of beta sheets other beta sheet domains an extended alpha helical domain a membrane proximal stem domain and a carboxyl terminal anchor. Proteomics computational analyses suggest that the structural functional motifs that characterize class III VFP are located collinearly in BDV G. Structural models