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Báo cáo khoa hoc : BRICHOS domain associated with lung fibrosis, dementia and cancer – a chaperone that prevents amyloid fibril formation?

REVIEW ARTICLE Hanna Willander1,2, EriThe BRICHOS domain was initially defined from sequence alignments of the Bri protein associated with familial dementia, chondromodulin associ-ated with chondrosarcoma and surfactant protein C precursor (proSP-C) associated with respiratory distress syndrome and interstitial lung disease (ILD). Today BRICHOS has been found in 12 protein families.k Hermansson2, Jan Johansson1,2 and Jenny Presto1,2 1 Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden 2 KI-Alzheimer’s Disease Research Center, NVS Department, Karolinska Institutet, Stockholm, Sweden Keywords Alzheimer’s disease; Bri; chaperone; dementia; lung fibrosis, proSP-C, protein misfolding Correspondence J. Presto, KI-Alzheimer’s disease research center, NVS department, Karolinska Institutet, Stockholm, Sweden Fax:.