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Optimization of synthesizing glucose 1-phosphate by sodium tripolyphosphate as a phosphorus acylating agent using response surface methodology

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With glucose as the starting material, sodium tripolyphosphate as the phosphorus acylating agent, and urea as the catalyst, glucose 1-phosphate was synthesized and its properties were analyzed. The synthesis conditions were selected according to the phosphorus content and optimized through the response surface methodology (RSM), based on a 3-level, 3-variable Box–Behnken experimental design. |

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