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Báo cáo y học: "Transcriptional control of dendritic patterning in Drosophila neurons"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Transcriptional control of dendritic patterning in Drosophila neurons. | Minireview Transcriptional control of dendritic patterning in Drosophila neurons Michel Tassetto and Fen-Biao Gao Address Gladstone Institute of Neurological Disease and Department of Neurology University of California San Francisco CA 94158 USA. Correspondence Fen-Biao Gao. Email fgao@gladstone.ucsf.edu Published 28 July 2006 Genome Biology 2006 7 225 doi 10.1186 gb-2006-7-7-225 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 7 225 2006 BioMed Central Ltd Abstract How the morphology of individual neurons is controlled remains poorly understood. A recent in vivo genome-wide screen based on RNA interference identified a large number of transcriptional factors that regulate the stereotyped growth and branching of dendrites on some Drosophila sensory neurons. Many neurons receive most of their input through thin processes called dendrites that form synapses with the axons of other neurons. Dendrites can be highly branched and have complex architecture. The shape and size of the dendrites of a single neuron determine the number and specificity of the axonal contacts it receives. Therefore the development of the correct pattern of dendritic branching or arborization on different neurons is essential for the proper functioning of the nervous system. Neuronal subtypes in mammals and insects can have specific patterns of dendrite branching 1 2 and several unbiased genome-wide forward genetic screens in Drosophila have identified factors that regulate dendritic morphogenesis in both the peripheral and central nervous systems 3-5 . But although these studies uncovered dozens of genes that might have essential roles in dendritic morphogenesis most of the genes have yet to be cloned and characterized and the information on genetic pathways has been sparse. Except for a few identified transcription factors that have been implicated in dendritic morphogenesis in flies and mammals 6-14 little is known about the .