Trong tiểu cầu, các phức này đi qua các cửa sổ nội mô (Hình 8,17) và đến nằm bên dưới màng nền. Các khu phức hợp có kích thước nhỏ nhất đi qua màng tầng hầm và dường như nhập vào nước tiểu. Đây có lẽ là cơ chế xử lý bình thường của cụm từ cơ thể. Phức hợp miễn dịch được hình thành trong nhiều, có lẽ hầu hết, các bệnh truyền nhiễm cấp tính. | 8 Mechanisms of Cell and Tissue Damage 283 choroid plexuses joints and ciliary body of the eye. Factors may include local high blood pressure and turbulent flow glomeruli or the filtering function of the vessels involved choroid plexus ciliary body . In the glomeruli the complexes pass through the endothelial windows Fig. and come to lie beneath the basement membrane. The smallest-sized complexes pass through the basement membrane and seem to enter the urine. This is probably the normal mechanism of disposal of such complexes from the body. Immune complexes are formed in many perhaps most acute infectious diseases. Microbial antigens commonly circulate in the blood in viral bacterial fungal protozoal rickettsial etc. infections. When the immune response has been generated and the first trickle of specific antibody enters the blood immune complexes are formed in antigen excess. This is generally a transitional stage soon giving rise to antibody excess as more and more antibody enters the blood and the GLOMERULONEPHRITIS Fig. Immune complex glomerulonephritis. Arrows indicate the movement of immune complex deposits some moving through to the urine and others larger deposits being retained. M mesangial cell u urinary space L lumen of glomerular capillary E endothelial cell contains 100 nm pores or windows see Fig. . 284 Mims Pathogenesis of Infectious Disease infection is terminated. Sometimes the localisation of immune complexes and complement in kidney glomeruli is associated with a local inflammatory response after complement activation. There is an infiltration of polymorphs swelling of the glomerular basement membrane loss of albumin even red blood cells in the urine and the patient has acute glomerulonephritis. This is seen following streptococcal infections mainly in children see below . As complexes cease to be formed the changes are reversed and complete recovery is the rule. Repeated attacks or persistent deposition of complexes leads to .
