Các kiểm soát phóng thích (CR) dưới hình thức oxycodone (OxyContin, Purdue Pharma, Stamford, CT) ĐÃ Trở thành cực phổ biến như năm giảm đau hiệu quả, đặc biệt Đối với ung thư liên quan đến bánh mì. Bởi vì nó có thể được thực hiện hai lần hàng ngày, nó tăng tuân thủ và hiệu quả hơn | Advances in Therapeutics and Diagnostics Controlled-Release Oxycodone Alan M. Levine MD and Richard K. Burdick CRNP The controlled-release CR form of oxycodone Oxy-Contin Purdue Pharma Stamford CT has become exceedingly popular as an effective analgesic especially for cancer-related pain. Because it can be taken twice daily it increases compliance and provides more effective relief by eliminating the need to catch up with the pain. Some studies have demonstrated the value of the CR formulations for both postoperative and chronic pain control. When used in patients with chronic pain oxycodone has the potential for abuse additionally patients who are chronically using the medication who undergo surgery may have a reduced therapeutic margin. For patients with musculoskeletal conditions such as chronic back and joint pain as well as for postoperative pain management the efficacy of CR oxycodone must be balanced with the potential risks of its use. These risks differ from those of shorter acting narcotics. In 2000 the number of first-time users of opiate pain relief reached 2 million. Survey data from the Drug Abuse Warning Network indicate that OxyContin has become one of the most commonly prescribed opiate medications emergency departments cite a 239 increase in use from 1996 to Structure and Mechanism of Action Oxycodone is a 4 5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride which has different pharmacokinetics and opioid receptor binding properties from morphine Fig. 1 . CR oxycodone is a pure opioid agonist whose primary therapeutic modality is analgesia. The mechanism of action of the analgesic effect is still unknown. However it acts on the central nervous system probably in opioid receptors for endogenous compounds that occur in both the brain and spinal cord. Oxycodone depresses the cough reflex by direct action on the cough center in the medulla and causes respiratory depression by acting directly on the respiratory centers in the .
