Toxicogenomics has been described as a discipline combining ex- pertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environ- ments. It includes the study of how genomes respond to toxicant expo- sures and how genotype affects responses to toxicant exposures. As the technologies for monitoring these responses rapidly develop, it is critical that scientists and regulators are confident that the technologies are reli- able and reproducible and that the data analyses have been validated. To discuss these issues in a public forum, the Committee on the Validation of Toxicogenomic Technologies designed a workshop to.