The prolyl oligopeptidase (POP) family of serine proteases includes prolyl oligopeptidase, dipeptidyl peptidase IV, acylaminoacyl peptidaseandoligopeptidase enzymes of this family specifically hydrolyze oligopeptides with less than 30 amino of the POP family enzymes have evoked pharmaceutical interest as they have roles in the regulationof peptide hormones and are involved in a variety of diseases such as dementia, trypanosomiasis and type 2 diabetes.