Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-fve substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM1 and PIM2 inhibitors having pIC50 ranging from to 9 µM and from to µM, respectively, using genetic function algorithm for variable selection and multiple linear regression analysis (MLR) to establish unambiguous and simple QSAR models based on topological molecular descriptors. | QSAR studies on PIM1 and PIM2 inhibitors using statistical methods A rustic strategy to screen for 5- 1H-indol-5-yl -1 3 4-thiadiazol analogues and predict their PIM inhibitory activity