Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise. | Ahmed Arthritis Research Therapy 2010 12 208 http content 12 2 208 REVIEW L_ Green tea polyphenol epigallocatechin 3-gallate in arthritis progress and promise Salahuddin Ahmed Abstract Green tea s active ingredient epigallocatechin 3-gallate EGCG has gained significant attention among scientists and has been one of the leading plant-derived molecules studied for its potential health benefits. In the present review I summarize the findings from some of the most significant preclinical studies with EGCG in arthritic diseases. The review also addresses the limitations of the dose pharmacokinetics and bioavailability of EGCG in experimental animals and findings related to the EGCG-drug interaction. Although these findings provide scientific evidence of the anti-rheumatic activity of EGCG further preclinical studies are warranted before phase clinical trials could be initiated with confidence for patients with joint diseases. Rheumatoid arthritis and osteoarthritis disease pathogenesis Rheumatoid arthritis RA is a chronic inflammatory disease characterized by the activation of synovial tissue lining the joint capsule which results in the invasion of the cartilage and bone leading to the progressive joint dysfunction 1 . Severe morbidity and structural damage of joints caused by chronic inflammation often lead to major personal family and financial consequences as well as increased mortality. Recent understanding of the RA pathogenesis has clarified the role of cytokines and other inflammatory mediators in this process and has provided a scientific rationale in the process of developing targeted therapies 2 . Osteoarthritis OA is a common disorder of synovial joints characterized pathologically by focal areas of damage to the articular cartilage centered on load-bearing Correspondence Department of Pharmacology 2232 Wolfe Hall College of Pharmacy 2801 W. Bancroft Street Toledo OH 43606 USA 2 BioMed Central 2010 BioMed
