Neurological Differential Diagnosis - part 5

Có một mối tương quan nghịch đảo giữa chiều dài lặp lại và tuổi bắt đầu. Các nguyên nhân của di truyền múa giật múa giật lành tính di truyền Neuroacanthocytosis múa giật Trung 2: Nhiễm trùng múa giật Sydenham Một nguyên nhân phổ biến ở trẻ em | 210 Chapters 1 Primary chorea Huntington disease The most common cause of chorea in adults. A trinucleotide repeat disorder CAG of chromosome 4 that causes the production of an abnormal protein called huntingtin. There is an inverse correlation between repeat length and age of onset. Other causes of hereditary chorea Benign hereditary chorea Neuroacanthocytosis 2 Secondary chorea Infections Sydenham chorea A common cause in childhood. Neurological complication of group A streptococcal infection. May occur as a part of manifestations of rheumatic fever. Acute onset clinical syndrome that involves chorea dysarthria weakness and behavior changes. Self-limited illness with a good prognosis for recovery. Other infectious causes d Bacterial and TB meningitis d Encephalitis HIV infection Drug-induced chorea Drugs known to cause chorea include neuroleptics dopamine agonists levodopa lithium cocaine and anticonvulsants. Chorea does not always remit with the discontinuation of the offending drug. Tardive dyskinesia is a term used when the chorea occurs after use of dopamine blocking agents for more than three months. Post-cardiac surgery in children Up to 10-18 of children with congenital heart disease post-bypass Typically resolves in weeks months Often associated with some cognitive disturbance Immune-mediated chorea 4 of patients with systemic lupus have chorea during exacerbation. Associated with antiphospholipid syndrome. Others Structural lesions of the striatum have been reported to cause chorea. Toxins such as carbon monoxide Multiple sclerosis Anoxic encephalopathy Chorea gravidarum Birth control pills Movement Disorders 211 Inherited neurological disorders with prominent chorea Orofacial dyskinesias and choreiform movements can be prominent manifestations of inherited diseases of the central nervous system. Chorea is characterized as primary when idiopathic or genetic in origin or secondary when related to infectious .

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