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báo cáo khoa học: "Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report | Nimmanon and Ruengpoka Journal of Medical Case Reports 2011 5 549 http www.jmedicalcasereports.eom content 5 1 549 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer a case report Thirayost Nimmanon1 and Poonkiat Ruengpoka2 Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer who presented to our facility with urinary incontinence. Initially our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis confirmed histologically and immunohistochemically as malignant fibrous histiocytoma with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore in a patient with a prior history of irradiation in the pelvic area this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment. Introduction While commonly found as a soft tissue tumor and considered as the most common soft tissue sarcoma in adults over the age of 40 years 1 malignant fibrous histiocytomas or the recently named undifferentiated high-grade pleomorphic sarcomas are periodically reported as the primary tumor in various organs including the urinary .