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báo cáo khoa học: "Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers | Ponti et al. Journal of Hematology Oncology 2010 3 2 http www.jhoonline.Org content 3 1 2 JOURNAL OF HEMATOLOGY ONCOLOGY CASE REPORT Open Access Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers Giovanni Ponti1 Gabriele Luppi1 Lorena Losi2 Alberto Giannetti3 Stefania Seidenari3 Abstract Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually the sign of Leser-Trélat is associated with adenocarcinoma most frequently of the colon breast or stomach but also of the lung kidney liver and pancreas. Herein we present a case that we believe is the first report of the sign of Leser-Trélat in association with occult gastric adenocarcinoma and the anamnestic oncologic history of five other multiple primitive cancers. Epidermal growth factor receptor EGFR immunohistochemical expression analysis of multiple seborrheic keratoses revealed an intense membranous staining in the basal keratinocytes and in all the upper epidermal layers. Patients with the sign of Leser-Trélat should undergo a diagnostic screening programme for malignant disease along with patients with known Leser-Trélat syndrome who present with a recent acute and florid eruption of their seborrheic keratoses. We propose the importance of combining the molecular features of multiple seborrheic keratoses with EGFR immunohistochemistry analyses to determine the likelihood of Leser-Trélat syndrome and the consequent high risk of underlying multiple visceral malignancies. Background Skin manifestations are frequently observed in many internal malignancies. Cutaneous lesions including benign neoplasms or pigmented lesions can appear in the context of specific genodermatosis 1 2 lentiginosis 3 or paraneoplastic syndrome 4 representing a crucial cutaneous marker of internal malignancy in both the sporadic and genetic setting. Several familial cancer syndromes have additional malignant