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báo cáo khoa học: " Primary choriocarcinoma of the renal pelvis presenting as intracerebral hemorrhage: a case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Primary choriocarcinoma of the renal pelvis presenting as intracerebral hemorrhage: a case report and review of the literature | Kyriakou et al. Journal of Medical Case Reports 2011 5 501 http www.jmedicalcasereports.eom content 5 1 501 TO. JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Primary choriocarcinoma of the renal pelvis presenting as intracerebral hemorrhage a case report and review of the literature 1 2 1 3 3 Fani Kyriakou Michael M Vaslamatzis Styliani Bastani Maria Alexandra Lianou Christina Vourlakou and Antonia Koutsoukou 1 Abstract Introduction A choriocarcinoma is a malignant neoplasm normally arising in the gestational trophoblast gonads and less frequently the retroperitoneum mediastinum and pineal gland. Primary choriocarcinomas of the renal pelvis are extremely rare. Case presentation We report a case of primary choriocarcinoma of the renal pelvis in a 38-year-old Greek woman of reproductive age presenting with a sudden development of intracerebral hemorrhage due to metastatic lesions. The diagnosis was established with a renal biopsy along with an elevated serum level of beta-human chorionic gonadotropin. An extensive diagnostic work up confirmed the origin of the choriocarcinoma to be the renal pelvis. Conclusion Extragonadal choriocarcinomas are rare neoplasms that require extensive laboratory and imaging studies to exclude a gonadal origin. Moreover this is the first case of severe intracerebral hemorrhage as the initial presentation of primary choriocarcinoma of the renal pelvis. Nonetheless choriocarcinomas should be considered in the differential diagnosis of women of reproductive age. Introduction A choriocarcinoma is a malignant neoplasm normally arising in the gestational trophoblast and gonads. Choriocarcinomas of the renal pelvis are extremely rare and they often present in association with transitional cell carcinoma TCC . Their presenting symptoms are flank pain and macrohematuria. We present a case of primary choriocarcinoma of the renal pelvis in a woman of reproductive age presenting with sudden development of intracerebral hemorrhage. Case .