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Báo cáo y học: " Renal cell carcinoma metastasis to the ciliary body responds to proton beam radiotherapy: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Renal cell carcinoma metastasis to the ciliary body responds to proton beam radiotherapy: a case report. | JOURNALOF MEDICAL CASE REPORTS Renal cell carcinoma metastasis to the ciliary body responds to proton beam radiotherapy a case report Alasil et al. BioMed Central Alasil et al. Journal of Medical Case Reports 2011 5 345 http www.jmedicalcasereports.com content 5Z1 345 3 August 2011 Alasil et al. Journal of Medical Case Reports 2011 5 345 http www.jmedicalcasereports.eom content 5 1 345 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Renal cell carcinoma metastasis to the ciliary body responds to proton beam radiotherapy a case report Tarek Alasil Bahram Khazai Lilia Loredo and Michael E Rauser Abstract Introduction We report an unexpected presentation of metastatic renal cell carcinoma RCC to the ciliary body and an interesting response to proton beam radiotherapy. Case presentation We encountered a case of angle-closure glaucoma as the initial presentation of ocular metastasis to the ciliary body in a 65-year-old Caucasian man who had undergone right radical nephrectomy for RCC 15 years earlier. He underwent YAG yttrium aluminium garnet laser peripheral iridotomy while further metastatic workup took place. His condition was eventually diagnosed as stage IV metastatic RCC of the clear cell type and involved multiple sites including the ciliary body brain lungs liver and pancreas. The progression of RCC metastasis to the ciliary body was studied for 16 months. The ciliary body mass continued to grow despite systemic treatment with temsirolimus and interleukin-2 and intravitreal injections of bevacizumab. The tumor size peaked at 6.11 X 6.06 mm before the start of proton therapy which reduced the tumor size to 5.07 X 4.39 mm. Conclusions RCC can produce metastases involving unusual sites many years after resection of the primary tumor. Proton therapy was found to be effective in treating RCC metastasis to the ciliary body in settings in which other treatment modalities failed. Introduction Renal cell carcinoma RCC accounts for approximately 85 of primary .