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Báo cáo y học: "Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report. | Elyassi et al. Journal of Medical Case Reports 2011 5 167 http www.jmedicalcasereports.eom content 5 1 167 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty a case report Ali R Elyassi Robert P Long Robert P Bejnarowicz and Bruce A Schoneboom Abstract Introduction The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor documentation whether or not gabapentin and ketamine interact to cause prolonged depression of the central nervous system. Case Presentation The following is a case report in which a patient a 58-year-old African-American man with a history of post-traumatic stress disorder and chronic pain underwent a cervical laminoplasty procedure. The patient presented post-operatively in a dissociative state with paralysis anarthria and preservation of consciousness. All organic causes were excluded with the exception of prolonged central nervous system depression from a gabapentin ketamine drug interaction. A new onset conversion disorder could also not be excluded. Conclusion Although this case by itself is not enough evidence to substantiate a true adverse reaction between gabapentin and ketamine it is enough to warrant further investigation. Introduction The incidence of post-traumatic stress disorder PTSD is undoubtedly on the rise given the recent events of the World Trade Center and Pentagon terrorist attacks coupled with the current wars in Iraq and Afghanistan. The prevalence of PTSD in the United States population is estimated to be approximately 8 . According to the Veterans Health Administration VHA Operation Iraqi Freedom OIF and Operation Enduring Freedom OEF veterans seeking VHA health care have been diagnosed predominantly with PTSD 1 2 . PTSD can give rise to pain as suggested by the high rates of chronic pain in patients with a history .