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báo cáo khoa học: "Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report | Faria et al. Journal of Medical Case Reports 2010 4 351 http www.jmedicalcasereports.eom content 4 1 351 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Primary gastric adenosquamous carcinoma in a Caucasian woman a case report 1 2 1 1 1 1 2 Gil R Faria Catarina Eloy John R Preto Eduardo L Costa Teresa Almeida José Barbosa Maria Emilia Paiva Joaquim Sousa-Rodrigues1 Amadeu Pimenta1 Abstract Introduction Most gastric tumors are adenocarcinomas. Primary gastric adenosquamous carcinoma is a rare malignancy mostly associated with Asian populations. It constitutes less than one percent of all gastric carcinomas and its clinical presentation is the same as adenocarcinoma. It occurs more frequently in the proximal stomach usually presents with muscular layer invasion and tends to be found in advanced stages at diagnosis with a worse prognosis than adenocarcinoma. Case presentation We report the case of an 84-year-old Caucasian woman with an adenosquamous carcinoma extending to her serosa with lymphatic and venous invasion T3N1M1 . Nodal and hepatic metastasis presented with both cellular types with dominance of the squamous component. Conclusions Adenosquamous gastric cancer is a rare diagnosis in western populations. We present the case of a woman with a very aggressive adenosquamous carcinoma with a preponderance of squamous cell component in the metastasis. Several origins have been proposed for this kind of carcinoma either evolution from adenocarcinoma de-differentiation or stem cell origin might be possible. The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach. Introduction Primary gastric adenosquamous carcinoma is a rare malignant neoplasia 1-3 . Most cases reported in the literature refer to Asian people 4-6 . It amounts to less than one percent of all gastric carcinomas and its clinical and endoscopic findings are similar to the .