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Báo cáo y học: " Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy. | Grande et al. Journal of Inflammation 2010 7 19 http www.journal-inflammation.eom content 7 1 19 JOURNAL OF INFLAMMATION REVIEW Open Access Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy María T Grande 1 2 Fernando Perez-Barriocanal1 2 and José M Lopez-Novoa 1 2 Abstract Obstructive nephropathy is characterized by an inflammatory state in the kidney that is promoted by cytokines and growth factors produced by damaged tubular cells infiltrated macrophages and accumulated myofibroblasts. This inflammatory state contributes to tubular atrophy and interstitial fibrosis characteristic of obstructive nephropathy. Accumulation of leukocytes especially macrophages and T lymphocytes in the renal interstitium is strongly associated to the progression of renal injury. Proinflammatory cytokines NF-kB activation adhesion molecules chemokines growth factors NO and oxidative stress contribute in different ways to progressive renal damage induced by obstructive nephropathy as they induce leukocytes recruitment tubular cell apoptosis and interstitial fibrosis. Increased angiotensin II production increased oxidative stress and high levels of proinflammatory cytokines contribute to NF-kB activation which in turn induce the expression of adhesion molecules and chemokines responsible for leukocyte recruitment and iNOS and cytokines overexpression which aggravates the inflammatory response in the damaged kidney. In this manuscript we revise the different events and regulatory mechanisms involved in inflammation associated to obstructive nephropathy. Introduction Obstructive nephropathy due to congenital or acquired urinary tract obstruction is the first primary cause of chronic renal failure CRF in children according to data of The North American Pediatric Renal Transplant Cooperative Study NAPRTCS 1 . Obstructive nephropathy is also a major cause of renal failure in adults 2 3 . The renal consequences of chronic urinary tract obstruction are .