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Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. | Journal of Inflammation BioMed Central Research Open Access Characterization of Toll-like receptors in primary lung epithelial cells strong impact of the TLR3 ligand poly I C on the regulation of Toll-like receptors adaptor proteins and inflammatory response Mirko Ritter Detlev Mennerich Andreas Weith and Peter Seither Address Department of Pulmonary Research Boehringer-Ingelheim Pharma GmbH Co. KG Birkendorfer StraPe 88937 Biberach a.d. Riss Germany Email Mirko Ritter - mirko.ritter@bc.boehringer-ingelheim.com Detlev Mennerich - detlev.mennerich@bc.boehringer-ingelheim.com Andreas Weith - andreas.weith@bc.boehringer-ingelheim.com Peter Seither - peter.seither@bc.boehringer-ingelheim.com Corresponding author Published 29 November 2005 Received 04 August 2005 Journal of Inflammation 2005 2 16 doi 10.1186 1476-9255-2-16 Accepted 29 November 2005 This article is available from http www.journal-inflammation.com content 2 1 16 2005 Ritter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bacterial and viral exacerbations play a crucial role in a variety of lung diseases including COPD or asthma. Since the lung epithelium is a major source of various inflammatory mediators that affect the immune response we analyzed the inflammatory reaction of primary lung epithelial cells to different microbial molecules that are recognized by Toll-like receptors TLR . Methods The effects of TLR ligands on primary small airway epithelial cells were analyzed in detail with respect to cytokine chemokine and matrix metalloproteinase secretion. In addition the regulation of the expression of TLRs and their adaptor proteins in small airway epithelial cells was investigated. Results Our data demonstrate that poly I C a .