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Báo cáo y học: "Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report. | Brown et al. Journal of Medical Case Reports 2010 4 204 http www.jmedicalcasereports.eom content 4 1 204 Ws JOURNALOF.MEDICAL CASE REPORTS CASE REPORT Open Access Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation a case report Keri Brown Jeanine Martin and Susan Zito Abstract Introduction Leukocytoclastic vasculitis also known as hypersensitivity vasculitis and cutaneous necrotizing vasculitis can present with various manifestations which often delays the diagnosis and treatment. In order to show the importance of the early recognition of leukocytoclastic vasculitis we present a case which occurred secondary to the use of a common pharmaceutical naproxen. We were unable to find a case of leukocytoclastic vasculitis secondary to naproxen in the literature. Case presentation We present the case of a 33-year-old African American woman with below the knee and bilateral digital gangrene from hypersensitivity vasculitis secondary to the non-steroidal anti-inflammatory medication naproxen. Conclusion This is an original case report focusing on the rheumatologic management of leukocytoclastic vasculitis. However other specialties such as internal medicine dermatology infectious disease general surgery and pathology can gain valuable information by reviewing this case report. Reporting a case of leukocytoclastic vasculitis secondary to treatment with naproxen will advance our understanding of this disease etiology by adding yet another nonsteroidal anti-inflammatory drug to the list of potential causes of leukocytoclastic vasculitis. Introduction The term leukocytoclastic vasculitis LCV has been used interchangeably with other descriptions of small-vessel vasculitides including drug-induced vasculitis allergic vasculitis hypersensitivity angiitis and hypersensitivity vasculitis HSV 1 . Leucocytoclastic angiitis is an isolated condition without systemic vasculitis or glomerulonephritis 2 3 . The American College of Rheumatology .