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Báo cáo y học: " Severe hydrops in the infant of a Rhesus D-positive mother due to anti-c antibodies diagnosed antenatally: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Severe hydrops in the infant of a Rhesus D-positive mother due to anti-c antibodies diagnosed antenatally: a case report. | Singla et al. Journal of Medical Case Reports 2010 4 57 http www.jmedicalcasereports.eom content 4 1 57 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Severe hydrops in the infant of a Rhesus D-positive mother due to anti-c antibodies diagnosed antenatally a case report Shilpa Singla Sunesh Kumar Kallol Kumar Roy Jai Bhagwan Sharma Garima Kachhawa Abstract Introduction Rhesus haemolytic disease of the newborn is a prototype of maternal isoimmunisation and fetal haemolytic disease. There are other rare blood group antigens capable of causing alloimmunisation and haemolytic disease such as c C E Kell and Duffy. In India after the confirmation of a newborn s blood group antibodies are screened only if the mother is Rehsus D-negative negative and the father is Rhesus D-positive. Hydrops in Rhesus positive women are investigated along the lines of non-immune hydrops. Case presentation We report the case of a patient from India where irregular antibodies were requested for an O-positive 26-year-old mother in order to investigate fetal hydrops. Anti-c antibody was revealed and the fetus was treated successfully with compatible O negative and c negative intrauterine blood transfusions. The baby was treated postnatally with double volume exchange transfusion with the same compatible blood and was discharged 30 days after birth. Conclusion We highlight the importance of conducting irregular antibody screening for women with significant obstetric history and fetal hydrops. This could assist in diagnosing and successfully treating the fetus with appropriate antigen negative cross-matched compatible blood. We note however that anti-c immunoglobulin is not yet readily available. Introduction Haemolytic disease of the newborn is a well-recognised entity because of the isoimmunisation of Rhesus D-negative mother in an Rh-positive fetus. Severe degrees of fetal hemolysis result in fetal hydrops 1 . Although anti-Rh D was once the major etiology of haemolytic disease