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báo cáo khoa học: " ABO blood group and other genetic variants associated with pancreatic cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: ABO blood group and other genetic variants associated with pancreatic cancer | Lennon et al. Genome Medicine 2010 2 39 http genomemedicine.eom content 2 6 39 w Genome Medicine MINIREVIEW L__ ABO blood group and other genetic variants associated with pancreatic cancer Anne Marie Lennon1 Alison P Klein2 3 4 and Michael Goggins1 2 3 Abstract Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States. Recent reports including genome-wide association studies and self-reported blood serotype studies have shown that individuals of European ancestry who carry non-O blood group are at an increased risk of developing pancreatic cancer. Two recent genomewide association studies of pancreatic cancer have identified associations between pancreatic cancer risk and genetic variants in the ABO blood group gene the locus containing the telomerase reverse transcriptase hTERT gene the nuclear receptor family gene NR5A2 and a non-genic region on chromosome 13q22.1. Pancreatic adenocarcinoma is the fourth leading cause of cancer death in men and women in the United States and has the lowest survival rate for any solid cancer. Over 42 000 individuals are diagnosed with pancreatic cancer in the United States each year and over 35 000 will die of the disease 1 . Similar mortality figures are reported in Europe with 1- and 5-year survival rates of only 15 and 4 respectively 2 . One important reason for this poor survival is that about 85 of patients present with advanced disease limiting our ability to treat the disease at an early curable stage 3 . For this reason there is considerable interest in identifying the disease in its earliest stages such as by screening high-risk individuals 4 identifying better diagnostic markers of early-stage disease 5 identifying familial and genetic risk factors that contribute to the disease 6 and ultimately developing risk prediction models to identify at-risk individuals 7 . Risk factors for pancreatic cancer include family history inheriting deleterious mutations in pancreatic .