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báo cáo khoa học: " Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? | Lee and Calin Genome Medicine 2010 2 77 http genomemedicine.eom content 2 10 77 Genome Medicine COMMENTARY Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality Sang Kil Lee -2 and George A Calin1 Abstract Synthetic RNA-based regulatory systems are used to program higher-level biological functions that could be exploited- among many applications- for in vivo diagnostic and therapeutic applications. Chen and colleagues have recently reported a significant technological advance by producing an RNA modular device based on a hammerhead ribozyme and successfully tested its ability to control the proliferation of mammalian T lymphocytes. Like all exciting research-this work raises a lot of significant questions. How quickly will such knowledge be translated into clinical practice How efficient will this system be in human clinical trials involving adaptive T-cell therapy We discuss the possible advantages of using such new technologies for specific therapeutic applications. In the past two decades molecular biology research has revealed the intimate mechanisms of epidemiologically significant diseases such as cancer infections and immunological disorders. As the next step beyond seeking the mechanisms involved scientists are now increasingly making it possible to regulate human biological reactions. In recent years there have been breakthroughs in genetic engineering related to the inventory and methods necessary to physically construct and assemble biomolecular parts such as synthetic RNA-based regulatory systems 1 . Synthetic biology relies on the engineering of biological systems that perform human-defined functions and on the synthesis of complex biologically based systems that show functions that do not exist in nature. Despite the possible Correspondence gcalin@mdanderson.org RNA interference and non-coding RNA Center and the Department of Experimental Therapeutics University of Texas MD Anderson Cancer .