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Báo cáo y học: " Primary bony non-Hodgkin lymphoma of the cervical spine: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Primary bony non-Hodgkin lymphoma of the cervical spine: a case report | Smith et al. Journal of Medical Case Reports 2010 4 35 http www.jmedicalcasereports.eom content 4 1 35 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Primary bony non-Hodgkin lymphoma of the cervical spine a case report Zachary A Smith Mark F Sedrak Larry T Khoo Abstract Introduction Non-Hodgkin lymphoma primarily originating from the bone is exceedingly rare. To our knowledge this is the first report of primary bone lymphoma presenting with progressive cord compression from an origin in the cervical spine. Herein we discuss the unusual location in this case the presenting symptoms and the management of this disease. Case presentation We report on a 23-year-old Caucasian-American man who presented with two months of night sweats fatigue parasthesias and progressive weakness that had progressed to near quadriplegia. Magnetic resonance MR imaging demonstrated significant cord compression seen primarily at C7. Surgical management with corpectomy and dorsal segmental fusion in combination with adjuvant chemotherapy and radiation therapy halted the progression of the primary disease and preserved neurological function. Histological analysis demonstrated an aggressive anaplastic large cell lymphoma. Conclusion Isolated primary bony lymphoma of the spine is exceedingly rare. As in our case the initial symptoms may be the result of progressive cervical cord compression. Anterior corpectomy with posterolateral decompression and fusion succeeded in preventing progressive neurologic decline and maintaining quality of life. The reader should be aware of the unique presentation of this disease and that surgical management is a successful treatment strategy. Introduction Primary vertebral lymphoma presenting without sites of systemic involvement is exceedingly rare. Bone is the primary origin of the disease in only 1 of non-Hodgkin lymphomas 1 . Further primary vertebral locations account for only 1.7 of all primary bone lymphomas and the vast majority occur in .