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Báo cáo y học: "Familial liability, obstetric complications and childhood development abnormalities in early onset schizophrenia: a case control study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Familial liability, obstetric complications and childhood development abnormalities in early onset schizophrenia: a case control study | Margari et al. BMC Psychiatry 2011 11 60 http www.biomedcentral.com 1471-244X 11 60 BMC Psychiatry RESEARCH ARTICLE Open Access Familial liability obstetric complications and childhood development abnormalities in early onset schizophrenia a case control study Francesco Margari1 Maria G Petruzzelli2 Paola A Lecce2 Orlando Todarello1 Andrea De Giacomo2 Elisabetta Lucarelli2 Domenico Martinelli3 and Lucia Margari2 Abstract Background Genetic and environmental risk factors and gene-environment interactions are linked to higher likelihood of developing schizophrenia in accordance with the neurodevelopmental model of disease little is known about risk factors and early development in early-onset schizophrenia EOS and very early-onset schizophrenia VEOS . Methods We present a case-control study of a sample of 21 patients with EOS VEOS and a control group of 21 patients with migraine recruited from the Child Neuropsychiatry Unit Department of Neurologic and Psychiatric Science University of Bari Italy. The aim was to assess the statistical association between VEOS EOS and family history for psychiatric disorders obstetric complications and childhood developmental abnormalities using 2x2 tables and a Chi Squared or Fisher test. Results The results show a statistical association between EOS VEOS and schizophrenia and related disorders P 0.02 and personality disorders P 0.003 in relatives and between EOS VEOS and developmental abnormalities of early relational skills P 0.008 and learning P 0.04 there is not a statistically relevant difference between cases and controls P 0.05 for any obstetric complications pre peri and postpartum . Conclusions This study confirms the significant role of familial liability but not of obstetric complications in the pathogenesis of VEOS EOS the association between childhood developmental abnormalities and EOS VEOS supports the neurodevelopmental model of disease. Background Early-onset schizophrenia EOS manifesting before the age of 18 years .