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Báo cáo y học: "Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive . | Morey et al. BMC Psychiatry 2011 11 76 http www.biomedcentral.com 1471-244X 11 76 BMC Psychiatry RESEARCH ARTICLE Open Access Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder D -X I zx t-x z l z-x A IV I zzxx Ĩ 1 2 3A l x ZV X -X zd D I_I ri r 12 4 Ạ L . I V r -X I I z l5 K í I A I_I XI I r zx z3 6 I_I zx I Z 1 I I IV II I zx zx zx z3 6 c I zx z I zx IH zx I Z zx r 7 Rajendra A Morey Ahmad R Hariri Andrea L Gold Micnaei A Hauser Heidi J Munger Florin DOICOS and Gregory McCarthy3 5 Abstract Background Serotonergic system dysfunction has been implicated in posttraumatic stress disorder PTSD . Genetic polymorphisms associated with serotonin signaling may predict differences in brain circuitry involved in emotion processing and deficits associated with PTSD. In healthy individuals common functional polymorphisms in the serotonin transporter gene SLC6A4 have been shown to modulate amygdala and prefrontal cortex PFC activity in response to salient emotional stimuli. Similar patterns of differential neural responses to emotional stimuli have been demonstrated in PTSD but genetic factors influencing these activations have yet to be examined. Methods We investigated whether SLC6A4 promoter polymorphisms 5-HTTLPR rs25531 and several downstream single nucleotide polymorphisms SNPs modulated activity of brain regions involved in the cognitive control of emotion in post-9 11 veterans with PTSD. We used functional MRI to examine neural activity in a PTSD group n 22 and a trauma-exposed control group n 20 in response to trauma-related images presented as task-irrelevant distractors during the active maintenance period of a delayed-response working memory task. Regions of interest were derived by contrasting activation for the most distracting and least distracting conditions across participants. Results In patients with PTSD when compared to trauma-exposed controls rs16965628 .