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báo cáo khoa học:" The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities | Teckle et al. Health and Quality of Life Outcomes 2011 9 106 http www.hqlo.eom content 9 1 106 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities 1.2.3 1.2.3 1.2 1.2 4 Paulos Teckle Stuart Peacock Helen McTaggart-Cowan Kim van der Hoek Stephen Chia Barb Melosky4 and Karen Gelmon4 Abstract Objective To evaluate the validity of cancer-specific and generic preference-based instruments to discriminate across different measures of cancer severities. Methods Patients with breast n 66 colorectal n 57 and lung n 61 cancer completed the EORTC QLQ-C30 and the FACT-G as well as three generic instruments the EQ-5D the SF-6D and the HUI2 3. Disease severity was quantified using cancer stage Eastern Cooperative Oncology Group Performance Status ECOG-PS score and self-reported health status. Comparative analyses confirmed the multi-dimensional conceptualization of the instruments in terms of construct and convergent validity. Results In general the instruments were able to discriminate across severity measures. The instruments demonstrated moderate to strong correlation with each other r 0.37-0.73 . Not all of the measures could discriminate between different groups of disease severity the EQ-5D and SF-6D were less discriminative than the HUI2 3 and the cancer-specific instruments. Conclusion The cancer-specific and generic preference-based instruments demonstrated to be valid in discriminating across levels of ECOG-PS scores and self-reported health states. However the usefulness of the generic instruments may be limited if they are not able to detect small changes in health status within cancer patients. This raises concerns regarding the appropriateness of these instruments when comparing different cancer treatments within an economic evaluation framework. Keywords Quality of life cancer-specific instruments generic .