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báo cáo khoa học:" Preferences for health outcomes associated with Group A Streptococcal disease and vaccination"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Preferences for health outcomes associated with Group A Streptococcal disease and vaccination | Lee et al. Health and Quality of Life Outcomes 2010 8 28 http www.hqlo.eom content 8 1 28 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Preferences for health outcomes associated with Group A Streptococcal disease and vaccination Grace M Lee1 2 Joshua A Salomon3 Charlene Gay1 James K Hammitt4 Abstract Background A 26-valent Group A Streptococcus GAS vaccine candidate has been developed that may provide protection against pharyngitis invasive disease and rheumatic fever. However recommendations for the use of a new vaccine must be informed by a range of considerations including parents preferences for different relevant health outcomes. Our objectives were to 1 describe parent preferences for GAS disease and vaccination using willingness-to-pay WTP and time trade-off TTO methods and 2 understand how parents implied WTP for a quality-adjusted life year QALY gained might vary depending on the particular health outcome considered e.g. averted GAS disease vs. vaccine adverse events . Methods Telephone interviews were conducted with parents of children diagnosed with GAS pharyngitis at 2 pediatric practice sites in the Boston metropolitan area. WTP and TTO trading parental longevity for child s health questions for 2 vaccine and 4 disease-associated health states were asked using a randomly selected opening bid followed by a 2nd bid and a final open-ended question about the amount willing to pay or trade. Descriptive analyses included medians and interquartile ranges for WTP and TTO estimates. The Wilcoxon signed-rank test was used to assess differences in WTP QALY values for vaccine adverse events vs. disease states. Results Of 119 respondents 100 84 and 96 81 provided a complete set of responses for WTP and TTO questions respectively. The median WTP and discounted at 3 per year TTO values to avoid each health state were as follows local reaction 30 0.12 days systemic reaction 50 0.22 days impetigo 75 1.25 days strep throat 75 2.5 days septic arthritis 1 000