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Báo cáo y học: "Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians | Jobarteh et al. Virology Journal 2010 7 230 http www.virologyj.eom content 7 1 230 VIROLOGY JOURNAL RESEARCH Open Access Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians Modou Jobarteh1 Marine Malfroy1 4 Ingrid Peterson1 Adam Jeng1 Ramu Sarge-Njie1 Abraham Alabi1 5 Kevin Peterson1 Matt Cotten1 Andrew Hall2 Sarah Rowland-Jones1 6 Hilton Whittle1 Richard Tedder3 Assan Jaye1 Maimuna Mendy1 Abstract Background The prevalence of HIV hepatitis co-infection in sub-Saharan Africa is not well documented while both HIV and HBV are endemic in this area. Objective The aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia. Methods Plasma samples from HIV infected patients 190 individuals with clinically defined AIDS and 382 individuals without AIDS were tested retrospectively for the presence of HBV sero-markers and for serum HBV DNA screened for HCV infection by testing for anti-HCV antibody and HCV RNA. Results HBsAg prevalence in HIV-positive individuals is 12.2 . HIV HBV co-infected individuals with CD4 count of 200 cells uL-1 have a higher HBV DNA viral load than patients with higher CD4 count log 4.0 vs. log 2.0 DNA copies ml p 0.05 . Males OR 1.8 95 CI 1.0 3.2 were more likely to be HBsAg positive than female. HCV seroprevalence was 0.9 in HIV-positive individuals. Conclusion The prevalence of HBsAg carriage in HIV- infected Gambians is similar to that obtained in the general population. However co-infected individuals with reduced CD4 levels indicative of AIDS had higher prevalence of HBeAg retention and elevated HBV DNA levels compared to non-AIDS patients with higher CD4 count. Background It is estimated that 350 million people world -wide are chronically infected with hepatitis B virus HBV and over 500 000 people die annually from HBV-related causes 1 2 . HBV Carriers are at a high risk of developing cirrhotic liver disease and hepatocellular carcinoma HCC the most frequent cause