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Báo cáo y học: " Bioelectrical impedance analysis in clinical practice: implications for hepatitis C therapy BIA and hepatitis C"

Bioelectrical impedance analysis in clinical practice: implications for hepatitis C therapy BIA and hepatitis C | Kahraman et al. Virology Journal 2010 7 191 http www.virologyj.eom content 7 1 191 VIROLOGY JOURNAL RESEARCH Open Access Bioelectrical impedance analysis in clinical practice implications for hepatitis C therapy BIA and hepatitis C 1 1.2 11 1 3 Alisan Kahraman Johannes Hilsenbeck Monika Nyga Judith Ertle Alexander Wree Mathias Plauth Guido Gerken1 Ali E Canbay1 Abstract Background Body composition analysis using phase angle PA determined by bioelectrical impedance analysis BIA reflects tissue electrical properties and has prognostic value in liver cirrhosis. Objective of this prospective study was to investigate clinical use and prognostic value of BIA-derived phase angle and alterations in body composition for hepatitis C infection HCV following antiviral therapy. Methods 37 consecutive patients with HCV infection were enrolled BIA was performed and PA was calculated from each pair of measurements. 22 HCV genotype 3 patients treated for 24 weeks and 15 genotype 1 patients treated for 48 weeks were examined before and after antiviral treatment and compared to 10 untreated HCV patients at 0 24 and 48 weeks. Basic laboratory data were correlated to body composition alterations. Results Significant reduction in body fat BF 24.2 6.7 kg vs. 19.9 6.6 kg genotype1 15.4 10.9 kg vs. 13.2 12.1 kg genotype 3 and body cell mass BCM 27.3 6.8 kg vs. 24.3 7.2 kg genotype1 27.7 8.8 kg vs. 24.6 7.6 kg genotype 3 was found following treatment. PA in genotype 3 patients was significantly lowered after antiviral treatment compared to initial measurements 5.9 0.7 vs. 5.4 0.8 . Total body water TBW was significantly decreased in treated patients with genotype 1 41.4 7.9 l vs. 40.8 9.5 l . PA reduction was accompanied by flu-like syndromes whereas TBW decline was more frequently associated with fatigue and cephalgia. Discussion BIA offers a sophisticated analysis of body composition including BF BCM and TBW for HCV patients following antiviral regimens. PA reduction was associated with .