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Báo cáo y học: "High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran | Karimi-Rastehkenari and Bouzari Virology Journal 2010 7 1 http www.virologyj.eom content 7 1 1 VIROLOGY JOURNAL RESEARCH Open Access High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran Abbas Karimi-Rastehkenari Majid Bouzari Abstract Background SEN virus is a blood-borne circular ssDNA virus and possessing nine genotypes A to I . Among nine genotypes SENV-D and SENV-H genotypes have the strong link with patients with unknown none-A to E hepatitis infections. Infection with blood-borne viruses is the second important cause of death in thalassemic patients. The aim of this study was to determine the frequency of SENV-D and SENV-H genotypes viremia by performing nested-PCR in 120 and 100 sera from healthy blood donors and thalassemic patients in Guilan Province North of Iran respectively. Also to explicate a possible role of SEN virus in liver disease and established changes in blood factors the serum aminotransferases ALT and AST and some of the blood factors were measured. Results Frequency of SENV-D SENV SENV-H or SENV-D and co-infection both SENV-D and SENV-H viremia was significantly higher among thalassemic patients than healthy individuals. Frequency of SENV-H viremia was significantly higher than SENV-D among healthy individuals. In comparison to SENV-D negative patients the mean of mean corpuscular hemoglobin was significantly higher in SENV-D positive and co-infection cases P 0.05 . The means of AST and ALT were significantly higher in thalassemic patients than healthy blood donors but there were not any significant differences in the means of the liver levels between SENV-positive and -negative individuals in healthy blood donors and thalassemic patients. High nucleotide homology observed among PCR amplicon s sequences in healthy blood donors and thalassemic patients. Conclusions The high rate of co-infection shows that different genotypes of SENV have no negative effects on each other. The high frequency of SENV .