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Báo cáo khoa học: " Feeling manipulated: cytomegalovirus immune manipulation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Feeling manipulated: cytomegalovirus immune manipulation | Virology Journal BioMed Central Open Access Review Feeling manipulated cytomegalovirus immune manipulation Mindy Miller-Kittrell and Tim E Sparer Address Department of Microbiology University of Tennessee 1414 Cumberland Ave. Knoxville TN USA Email Mindy Miller-Kittrell - mmille14@utk.edu Tim E Sparer - tsparer@utk.edu Corresponding author Published 9 January 2009 Received 18 September 2008 Accepted 9 January 2009 Virology Journal 2009 6 4 doi l0.ll86 l743-422X-6-4 This article is available from http www.virologyj.cOm content 6 1 4 2009 Miller-Kittrell and Sparer licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract No one likes to feel like they have been manipulated but in the case of cytomegalovirus CMV immune manipulation we do not really have much choice. Whether you call it CMV immune modulation manipulation or evasion the bottom line is that CMV alters the immune response in such a way to allow the establishment of latency with lifelong shedding. With millions of years of coevolution within their hosts CMVs like other herpesviruses encode numerous proteins that can broadly influence the magnitude and quality of both innate and adaptive immune responses. These viral proteins include both homologues of host proteins such as MHC class I or chemokine homologues and proteins with little similarity to any other known proteins such as the chemokine binding protein. Although a strong immune response is launched against CMV these virally encoded proteins can interfere with the host s ability to efficiently recognize and clear virus while others induce or alter specific immune responses to benefit viral replication or spread within the host. Modulation of host immunity allows survival of both the virus and the host. One way