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Báo cáo hóa học: "Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization | Donnem et al. Journal of Translational Medicine 2011 9 6 http www.translational-medicine.eom content 9 1 6 TRANSLATIONAL MEDICINE RESEARCH Open Access Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization I rn 3 m 1 2 m r I rn zn CLI r 3 4 I h m nr Dm rm 3 4 c m I m I I m m A c m r Ln m3 4 14 m m m zsh Ln I m m 1 I 3 4 c -n K m r Al c -n -n ml 3 4 Tom Donnem Katrine EKlo Tnomas Derg Sveinung W Sorbye Kenneth LonviK Samer Al-Saad I I I I Al ml I 1 3.5 m A I 12 I I I . I 112 n 12 I I I T- m 134 Khalid Al-Shibli Sigve Andersen Helge StenvolQ Roy M Bremnes Lill-Tove BusunQ Abstract Background In recent years microRNAs miRNAs have been found to play an essential role in tumor development. In lung tumorigenesis targets and pathways of miRNAs are being revealed and further translational research in this field is warranted. MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer NSCLC patients. Methods Tumor tissue samples from 335 resected stage I to IIIA NSCLC patients were obtained and tissue microarrays TMAs were constructed with four cores from each tumor specimen. In situ hybridization ISH was used to evaluate the expression of miR-155. Results There were 191 squamous cell carcinomas SCCs 95 adenocarcinomas ACs 31 large cell carcinomas and 18 bronchioalveolar carcinomas. MiR-155 expression did not have a significant prognostic impact in the total cohort P 0.43 . In ACs high miR-155 expression tended to a significant negative prognostic effect on survival in univariate analysis P 0.086 and was an independent prognostic factor in multivariate analysis HR 1.87 CI 95 1.01 - 3.48 P 0.047 . In SCC patients with lymph node metastasis however miR-155 had a positive prognostic impact on survival in univariate P 0.034 as well as in multivariate HR 0.45 CI 95 0.21-0.96 P 0.039 analysis. Conclusions The