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Báo cáo sinh học: " Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes | Virology Journal BioMed Central Open Access Attenuation and efficacy of human parainfluenza virus type I HPIV1 vaccine candidates containing stabilized mutations in the P C and L genes Emmalene J Bartlett Adam Castano Sonja R Surman Peter L Collins Mario H Skiadopoulos and Brian R Murphy Address Laboratory of Infectious Diseases Respiratory Viruses Section National Institute of Allergy and Infectious Diseases NIAID National Institutes of Health NIH Department of Health and Human Services Bethesda MD USA Email Emmalene J Bartlett - ebartlett@niaid.nih.gov Adam Castano - adam.castano@gmail.com Sonja R Surman - SBarbagallo@niaid.nih.gov Peter L Collins - PCOLLINS@niaid.nih.gov Mario H Skiadopoulos - mskiadopoulos@niaid.nih.gov Brian R Murphy - bmurphy@niaid.nih.gov Corresponding author Published 2 July 2007 Received 5 April 2007 Accepted 2 July 2007 Virology Journal 2007 4 67 doi l0.ll86 l 743-422X-4-67 This article is available from http www.virologyj.cOm content 4 1 67 2007 Bartlett et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Two recombinant live attenuated human parainfluenza virus type 1 rHPIVi mutant viruses have been developed using a reverse genetics system for evaluation as potential intranasal vaccine candidates. These rHPIVi vaccine candidates have two non-temperature sensitive non-ts attenuating att mutations primarily in the P C gene namely CR84GHNT553A two point mutations used together as a set and CAi70 a short deletion mutation and two ts att mutations in the L gene namely LY942A a point mutation and LAi7i0-ii a short deletion the last of which has not been previously described. The latter three .