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Báo cáo sinh học: "The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance | Xie et al. Journal of Translational Medicine 2011 9 95 http www.translational-medicine.eom content 9 1 95 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access The impact of Metastasis Suppressor-1 MTSS1 on oesophageal squamous cell carcinoma and its clinical significance I- w 1.2 1 2 2 -71 71 2 X X 2 2 1 Fei Xie 1 Lin Ye Jinfeng Chen Nan Wu Zhiqian Zhang Yue Yang Lijian Zhang and Wen G Jiang Abstract Background Metastasis suppressor-1 MTSS1 has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma ESCC has not been reported. Methods In this study we assessed the expression levels of MTSS1 in tumours and its matched adjacent nontumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells. Results Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade p 0.024 lymph node metastasis p 0.010 and overall survival p 0.035 . Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells by reducing their cellular migration and in vitro invasiveness. Conclusion MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy. Keywords metastasis suppressor-1 MTSS1 MIM oesophageal squamous cell carcinoma metastasis Background Tumour metastasis is the most significant contributor to the mortality of patients with .