Đang chuẩn bị liên kết để tải về tài liệu:
Wide Spectra of Quality Control Part 8

Tham khảo tài liệu 'wide spectra of quality control part 8', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 200 Wide Spectra of Quality Control results acetone isopropanol and methyl acetate were found in the product. Besides acetone and isopropanol were used in the synthesis methyl acetate was not included. The confirmation database was used to confirm the screening results. According to the result from GC-MS Ethyl acetate was the rank 1 compound according to the standard mass spectra library and the similarity value was 913 Fig. 4.a . The sample was analyzed by GC-FTIR using the standard vapor-phase infrared spectra library. Methyl acetate was also the rank 1 compound and the similarity value was 983 Fig. 4.b . The screening result was confirmed by the confirmation database and methyl acetate was confirmed in the product. 4.3 Method optimization database After the databases for screening and confirmation of residual solvents in pharmaceuticals were established our next challenge is to focus on systematic method development and optimization such as the fast selection of appropriate columns and optimization of chromatographic conditions. The solvation parameter model was applied in the development of a method for the analysis of residual solvents in pharmaceuticals. The interactions between organic solvents and six different stationary phases were studied using gas chromatography. The retention times of the organic solvents on these columns could be predicted under isothermal or temperature-programmed conditions using the established solvation parameter models. The predicted retention times helped in column selection and in optimizing chromatographic conditions during method development and will form the basis for the development of a computer-aided method. The solvation parameter model first introduced by Abraham Abraham 1994a 1994b 1997 is a useful tool for delineating the contribution of defined intermolecular interactions to the retention of neutral molecules in separation systems based on a solute equilibrium between a gas mobile phase and a liquid stationary phase.