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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers | Sauvain et al. Journal of Occupational Medicine and Toxicology 2011 6 18 http www.occup-med.eom content 6 1 18 _ JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers 1 t 14t 1 2 f I 2 1 Jean-Jacques Sauvain Ari Setyan Pascal Wild Philippe Tacchini Grégoire Lagger Ferdinand Storti Simon Deslarzes1 Michel Guillemin1 Michel J Rossi3 and Michael Riediker1 Abstract Background Exposure to particles PM induces adverse health effects cancer cardiovascular and pulmonary diseases . A key-role in these adverse effects seems to be played by oxidative stress which is an excess of reactive oxygen species relative to the amount of reducing species including antioxidants the first line of defense against reactive oxygen species. The aim of this study was to document the oxidative stress caused by exposure to respirable particles in vivo and to test whether exposed workers presented changes in their urinary levels for reducing species. Methods Bus depot workers n 32 exposed to particles and pollutants respirable PM4 organic and elemental carbon particulate metal content polycyclic aromatic hydrocarbons NOx O3 were surveyed over two consecutive days. We collected urine samples before and after each shift and quantified an oxidative stress biomarker 8-hydroxy-2 -deoxyguanosine the reducing capacity and a biomarker of PAH exposure 1-hydroxypyrene . We used a linear mixed model to test for associations between the oxidative stress status of the workers and their particle exposure as well as with their urinary level of reducing species. Results Workers were exposed to low levels of respirable PM4 range 25-71 pg m3 . However urinary levels of 8-hydroxy-2 -deoxyguanosine increased significantly within each shift and between both days for non-smokers. The between-day increase was significantly correlated p 0.001 with the concentrations of organic carbon NOx and .