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báo cáo hóa học:" The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study | Journal of Orthopaedic Surgery and Research Research article BioMed Central Open Access The effect of newer anti-rheumatic drugs on osteogenic cell proliferation an in-vitro study Ajay Malviya 1 Jan Herman Kuiper2 Nilesh Makwana3 Patrick Laing3 and Brian Ashton4 Address 1Wansbeck General Hospital Woodhorne Lane Ashington Northumberland NE63 9JJ UK 2Joint Reconstruction Unit Robert Jones and Agnes Hunt Orthopaedic Hospital Oswestry SY10 7AG UK 3Orthopaedic Department Robert Jones and Agnes Hunt Orthopaedic Hospital Oswestry SY10 7AG UK and 4Arthritis Research Centre Robert Jones and Agnes Hunt Orthopaedic Hospital Oswestry SY10 7AG UK Email Ajay Malviya - malviya7@aol.com Jan Herman Kuiper - Jan.Kuiper@rjah.nhs.uk Nilesh Makwana - NILESH.MAKWANA@new-tr.wales.nhs.uk Patrick Laing - pwl@dfoot.fsbusiness.co.uk Brian Ashton - brian.ashton7@btinternet.com Corresponding author Published 26 May 2009 Received 9 May 2008 Journal of Orthopaedic Surgery and Research 2009 4 17 doi 10.1186 1749-799X-4-17 Accepted 26 May 2009 This article is available from http www.josr-online.cOm content 4 1 17 2009 Malviya et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Disease modifying anti-rheumatic drugs DMARDs may interfere with bone healing. Previous studies give conflicting advice regarding discontinuation of these drugs in the perioperative setting. No consensus exists in current practice especially with the newer DMARDs such as Leflunomide Etanercept and Infliximab. The aim of this study was to assess the in-vitro effect of these drugs alone and in relevant clinical combinations on Osteoblast activity. Methods Osteoblasts were cultured from femoral heads obtained from five young otherwise healthy patients undergoing .