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Báo cáo hóa học: " Evidence of structural genomic region recombination in Hepatitis C virus"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Evidence of structural genomic region recombination in Hepatitis C virus | Virology Journal BioMed Central Research Open Access Evidence of structural genomic region recombination in Hepatitis C virus Juan Cristina 1 and Rodney Colina1 2 Address 1Laboratorio de Virología Molecular Centro de Investigaciones Nucleares Facultad de Ciencias Universidad de la República Iguá 4225 11400 Montevideo Uruguay and 2Department of Biochemistry and McGill Cancer Center McGill University Montreal Quebec H3G 1Y6 Canada Email Juan Cristina - cristina@cin.edu.uy RodneyColina- rcolina@cin.edu.uy Corresponding author Published 30 June 2006 Received 14 April 2006 Accepted 30 June 2006 Virology Journal 2006 3 53 doi 10.1186 1743-422X-3-53 This article is available from http www.virologyj.cOm content 3 1 53 2006 Cristina and Colina licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Aim Hepatitis C virus HCV has been the subject of intense research and clinical investigation as its major role in human disease has emerged. Although homologous recombination has been demonstrated in many members of the family Flaviviridae to which HCV belongs there have been few studies reporting recombination on natural populations of HCV. Recombination break-points have been identified in non structural proteins of the HCV genome. Given the implications that recombination has for RNA virus evolution it is clearly important to determine the extent to which recombination plays a role in HCV evolution. In order to gain insight into these matters we have performed a phylogenetic analysis of 89 full-length HCV strains from all types and sub-types isolated all over the world in order to detect possible recombination events. Method Putative recombinant sequences were identified with the use of SimPlot program. Recombination .