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báo cáo hóa học:" Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits | Wang et al. Journal of Translational Medicine 2011 9 61 http www.translational-medicine.eom content 9 1 61 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits Meitang Wang1 Tao Liu1 Dian Wang2 Yonghua Zheng2 Xiangdong Wang2 and Jian He1 Abstract Background Acute lung injury ALI and acute respiratory distress syndrome ARDS is an early characteristic of multiple organ dysfunction responsible for high mortality and poor prognosis in patients. The present study aims to evaluate therapeutic effects and mechanisms of pyrrolidine dithiocarbamate PDTC on ALI. Methods Alveolar-arterial oxygen difference lung tissue edema and compromise NF-kB activation in polymorphonuclear neutrophil PMN and systemic levels of tumor necrosis factor-alpha TNFa and intercellular adhesion molecule-1 ICAM-1 in rabbits induced by the intravenous administration of lipopolysaccharide LPS and treated with PDTC. Production of TNFa and IL-8 activation of Cathepsin G and PMNs adhesion were also measured. Results The intravenous administration of PDTC had partial therapeutic effects on endotoxemia-induced lung tissue edema and damage neutrophil influx to the lung alveolar-capillary barrier dysfunction and high systemic levels of TNFa and ICAM-1 as well as over-activation of NF-kB. PDTC could directly and partially inhibit LPS-induced TNFa hyper-production and over-activities of Cathepsin G. Such inhibitory effects of PDTC were related to the various stimuli and enhanced through combination with PI3K inhibitor. Conclusion NF-kB signal pathway could be one of targeting molecules and the combination with other signal pathway inhibitors may be an alternative of therapeutic strategies for ALI ARDS. Keywords acute lung injury TNF-a a ICAM-1 NF-K K B pyrrolidine dithiocarbamate Background Acute lung injury ALI and acute respiratory distress syndrome ARDS is an early characteristic of multiple organ dysfunction which is .