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báo cáo hóa học:" Poor Efficacy and Tolerability of Stavudine, Didanosine, and Efavirenz-based Regimen in Treatment-Naive Patients in Senegal"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Poor Efficacy and Tolerability of Stavudine, Didanosine, and Efavirenz-based Regimen in Treatment-Naive Patients in Senegal | Journal of the International AIDS Society BioMed Central Research article Poor Efficacy and Tolerability of Stavudine Didanosine and Efavirenz-based Regimen in Treatment-Naive Patients in Senegal Anna Canestri1 Papa Salif Sow2 Muriel Vray3 Fatou Ngom2 Souleymane M boup4 Coumba Toure Kane4 Eric Delaporte5 Mandoumé Gueye6 Gilles Peytavin7 Pierre Marie Girard1 Roland Landman 1 for the ANRS 1206 IMEA 012 Trial Study Group Address 1Institut de Médecine et d Epidémiologie Appliquée Bichat Claude Bernard Hospital Paris France 2Fann University Teaching Hospital and Centre Croix-Rouge de Traitement Ambulatoire Dakar Senegal 3Institut Pasteur Paris France 4Le Dantec University Teaching Hospital Dakar Senegal 5Institut de Recherche et Développement Montpellier France 6Hospital Principal Dakar Senegal and 7Pharmacology Laboratory Bichat-Claude-Bernard Hospital Paris France Email Roland Landman - landman@bichat.inserm.fr Corresponding author Open Access Published 9 October 2007 Journal of the International AIDS Society 2007 9 7 This article is available from http www.jiasociety.Org content 9 4 7 Abstract Objective To study the effectiveness and tolerance of an antiretroviral therapy ART regimen composed of the antiretroviral agents ARVs stavudine d4T plus didanosine ddl plus efavirenz EFV in patients with advanced HIV infection in Senegal. Design and methods This was an open-label single-arm 18-month trial in treatment-naive patients. The primary virologic end point was the percentage of patients with plasma HIV RNA 500 copies mL at months 6 M6 12 M12 and 18 M18 . The primary analysis was done as intent-to-treat. Results The staging of HIV disease performed using the definitions of the US Centers for Disease Control and Prevention CDC was CDC stage B or C for all 40 recruited patients. At baseline the mean CD4 cell count was 133 92 mcL standard deviation SD range 1346 and 23 of patients had CD4 cell counts below 50 mcL. The mean baseline plasma HIV RNA level was 5.5 0.4 log10 .