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báo cáo hóa học:" Association of hypoglycemic symptoms with patients’ rating of their health-related quality of life state: a cross sectional study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Association of hypoglycemic symptoms with patients’ rating of their health-related quality of life state: a cross sectional study | Alvarez-Guisasola et al. Health and Quality of Life Outcomes 2010 8 86 http www.hqlo.eom content 8 1 86 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Association of hypoglycemic symptoms with patients rating of their health-related quality of life state a cross sectional study 1 2 3 2 2 Fernando Alvarez-Guisasola Donald D Yin Gonzalo Nocea Ying Qiu Panagiotis Mavros Abstract Background To evaluate the association between patient-reported hypoglycemic symptoms with ratings of their health-related quality of life state and patient-reported adverse events in patients with type 2 diabetes mellitus T2DM . Methods This observational multicenter cross sectional study was based on a sample of patients with T2DM from seven European countries who added sulfonylurea or thiazolidinedione to metformin monotherapy between January 2001 and January 2006. Included patients were required to have at least one hemoglobin A1c HbA1c measurement in the 12 months before enrollment and to not be receiving insulin. Demographic and clinical data from medical records were collected using case report forms. Questionnaires measured patient-reported hypoglycemic symptoms health-related quality of life EuroQol visual analogue scale EQ-5D VAS and treatment-related adverse events. Results A total of 1 709 patients were included in the study. Mean patient age was 63 years 45 were female mean HbA1c was 7.06 and 28 were at HbA1c goal HbA1c 6.5 . Hypoglycemic symptoms during the 12 months before enrollment were reported by 38 of patients among whom 68 reported their most severe symptoms were mild 27 moderate and 5 severe. Adjusted linear regression analyses revealed that patients reporting hypoglycemic symptoms had significantly lower EQ-5D VAS scores indicating worse patient-reported quality of life mean difference -4.33 p 0.0001 . Relative to those not reporting symptoms the adjusted decrement to quality of life increased with greater hypoglycemic symptom severity mild -2.68 p 0.0039 .