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Báo cáo hóa học: " Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure? | Kozlov et al. Annals of Intensive Care 2011 1 41 http www.annalsofintensivecare.eom content 1 1 41 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access Mitochondrial dysfunction and biogenesis do ICU patients die from mitochondrial failure 1 1 2 13 4 Andrey V Kozlov Soheyl Bahrami Enrico Calzia Peter Dungel Lars Gille Andrey V Kuznetsov and Jakob Troppmair5 Abstract Mitochondrial functions include production of energy activation of programmed cell death and a number of cell specific tasks e.g. cell signaling control of Ca2 metabolism and synthesis of a number of important biomolecules. As proper mitochondrial function is critical for normal performance and survival of cells mitochondrial dysfunction often leads to pathological conditions resulting in various human diseases. Recently mitochondrial dysfunction has been linked to multiple organ failure MOF often leading to the death of critical care patients. However there are two main reasons why this insight did not generate an adequate resonance in clinical settings. First most data regarding mitochondrial dysfunction in organs susceptible to failure in critical care diseases liver kidney heart lung intestine brain were collected using animal models. Second there is no clear therapeutic strategy how acquired mitochondrial dysfunction can be improved. Only the benefit of such therapies will confirm the critical role of mitochondrial dysfunction in clinical settings. Here we summarized data on mitochondrial dysfunction obtained in diverse experimental systems which are related to conditions seen in intensive care unit ICU patients. Particular attention is given to mechanisms that cause cell death and organ dysfunction and to prospective therapeutic strategies directed to recover mitochondrial function. Collectively the data discussed in this review suggest that appropriate diagnosis and specific treatment of mitochondrial dysfunction in ICU patients may significantly improve the clinical outcome. .