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Báo cáo hóa học: "A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability, and pharmacokinetics and pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability, and pharmacokinetics and pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock | Critical Care This Provisional PDF corresponds to the article as it appeared upon acceptance. Copyedited and fully formatted PDF and full text HTML versions will be made available soon. A placebo-controlled double-blind dose-escalation study to assess the safety tolerability and pharmacokinetics and pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock Critical Care 2012 16 R31 doi 10.1186 cc11203 Peter E Morris pemorris@wfubmc.edu Brian Zeno BZENO2@OhioHealth.com Andrew C Bernard acbern00@email.uky.edu Xiangning Huang Xiangning.Huang@astrazeneca.com Shampa Das shampa.das@astrazeneca.com Timi Edeki timi.edeki@astrazeneca.com Steven G Simonson steve.simonson@agennix.com Gordon R Bernard gordon.bernard@Vanderbilt.Edu ISSN 1364-8535 Article type Research Submission date 24 October 2011 Acceptance date 17 February 2012 Publication date 17 February 2012 Article URL http ccforum.com content 16 1 R31 This peer-reviewed article was published immediately upon acceptance. It can be downloaded printed and distributed freely for any purposes see copyright notice below . Articles in Critical Care are listed in PubMed and archived at PubMed Central. For information about publishing your research in Critical Care go to http ccforum.com authors instructions 2012 Morris et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. A placebo-controlled double-blind dose-escalation study to assess the safety tolerability and pharmacokinetics pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock Peter E Morris 1 Brian Zeno 2 Andrew C Bernard 3 Xiangning Huang 4 Shampa Das 4 Timi Edeki 5 Steven G Simonson 6 and Gordon R