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Báo cáo hóa học: "Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images | Hindawi Publishing Corporation EURASIP Journal on Applied Signal Processing Volume 2006 Article ID 45684 Pages 1-13 DOI 10.1155 ASP 2006 45684 Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images Sabarish Babu 1 Pao-Chuan Liao 1 Min C. Shin 1 and Leonid V. Tsap2 1 Department of Computer Science University of North Carolina at Charlotte 9201 University City Boulevard Charlotte NC 28223 USA 2 Systems Research Group Electronics Engineering Department University of California Lawrence Livermore National Laboratory Livermore CA 94551 USA Received 27 April 2005 Revised 12 October 2005 Accepted 21 December 2005 The objectives of this work include automatic recovery and visualization of a 3D chromosome structure from a sequence of 2D tomographic reconstruction images taken through the nucleus of a cell. Structure is very important for biologists as it affects chromosome functions behavior of the cell and its state. Analysis of chromosome structure is significant in the detection of diseases identification of chromosomal abnormalities study of DNA structural conformation in-depth study of chromosomal surface morphology observation of in vivo behavior of the chromosomes over time and in monitoring environmental gene mutations. The methodology incorporates thresholding based on a histogram analysis with a polyline splitting algorithm contour extraction via active contours and detection of the 3D chromosome structure by establishing corresponding regions throughout the slices. Visualization using point cloud meshing generates a 3D surface. The 3D triangular mesh of the chromosomes provides surface detail and allows a user to interactively analyze chromosomes using visualization software. Copyright 2006 Hindawi Publishing Corporation. All rights reserved. 1. INTRODUCTION 1.1. Motivation Tracking and visualizing chromosomes gives biologists valuable information regarding their three-dimensional 3D structure and behavior. Previously .