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Báo cáo hóa học: " Comparative Genomics via Wavelet Analysis for Closely Related Bacteria"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Comparative Genomics via Wavelet Analysis for Closely Related Bacteria | EURASIP Journal on Applied Signal Processing 2004 1 5-12 2004 Hindawi Publishing Corporation Comparative Genomics via Wavelet Analysis for Closely Related Bacteria Jiuzhou Song Department of Biochemistry and Molecular Biology Faculty of Medicine University of Calgary 3330 Hospital Drive NW Calgary Alberta Canada T2N 4N1 Email songj@ucalgary.ca Tony Ware Department of Biochemistry and Molecular Biology Faculty of Medicine University of Calgary 3330 Hospital Drive NW Calgary Alberta Canada T2N 4N1 Email tware@ucalgaryca Shu-Lin Liu Department of Biochemistry and Molecular Biology Faculty of Medicine University of Calgary 3330 Hospital Drive NW Calgary Alberta Canada T2N 4N1 Email slliu@ucalgary.ca M. Surette Department of Biochemistry and Molecular Biology Faculty of Medicine University of Calgary 3330 Hospital Drive NW Calgary Alberta Canada T2N 4N1 Email surette@ucalgaryca Received 26 February 2003 Revised 11 September 2003 Comparative genomics has been a valuable method for extracting and extrapolating genome information among closely related bacteria. The efficiency of the traditional methods is extremely influenced by the software method used. To overcome the problem here we propose using wavelet analysis to perform comparative genomics. First global comparison using wavelet analysis gives the difference at a quantitative level. Then local comparison using keto-excess or purine-excess plots shows precise positions of inversions translocations and horizontally transferred DNA fragments. We firstly found that the level of energy spectra difference is related to the similarity of bacteria strains it could be a quantitative index to describe the similarities of genomes. The strategy is described in detail by comparisons of closely related strains S.typhi CT18 S.typhi Ty2 S.typhimurium LT2 H.pylori 26695 and H.pylori J99. Keywords and phrases comparative genomics gene discovery wavelet analysis bacterial genome. 1. INTRODUCTION Since the publication of the whole .