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Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells

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Ligand-induced oligomerization of receptors is a key step in initiating growth factor signaling. Nevertheless, complex biological responses often require additionaltrans-signaling mechanisms involving two or more signaling cascades. For cells of neuronal origin, it was shown that neurotrophic effects evoked by nerve growth factor or other neurotro-phins dependhighlyon the cooperativitywith cytokines that belong to the transforming growth factor b (TGF-b) superfamily. We found that rat pheochromocytoma cells, which represent amodel systemfor neuronal differentiation, are unresponsive to TGF-b1 due to limiting levels of its receptor, TbRII

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