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Willughbeia cochinchinensis ameliorates locomotor disorders in model of alzheimer’s disease mice

Objectives: To evaluate the effects of willughbela cochinchinessis (WC) to locomotor disorders in an Alzheimer's disease (AD) model of mice. Subjects and methods: 50 Swiss mice were separated randomly into 5 experimental groups, 10 mice for each group. | Journal of military pharmaco-medicine No7-2017 WILLUGHBEIA COCHINCHINENSIS AMELIORATES LOCOMOTOR DISORDERS IN MODEL OF ALZHEIMER’S DISEASE MICE Can Van Mao*; Tran Hai Anh*; Le Van Quan* SUMMARY Objectives: To evaluate the effects of willughbela cochinchinessis (WC) to locomotor disorders in an Alzheimer's disease (AD) model of mice. Subjects and methods: 50 Swiss mice were separated randomly into 5 experimental groups, 10 mice for each group. Group 1: Mice were intraperitoneally injected (i.p) and orally administered (p.o) saline at dose 0.1 mL/10 g; group 2: mice were injected i.p scopolamin 1.5 mg/kg and p.o saline 0.1 mL/10 g; group 3, group 4 and group 5: mice were injected i.p scopolamine 1.5 mg/kg and p.o WC 100 mg/kg, 150 mg/kg and 200 mg/kg, respectively. WC and saline were orally administered at 60 minutes and scopolamin and saline were injected i.p at 30 minutes before the behavioral task. 60 minutes after WC injections, mice were placed in an open field for 5 minutes. Behaviors of mice were observed by a camera and analyzed by Anymaze software. Results: WC at doses 150 mg/kg and 200 mg/kg reversed scopolamin-induced hyperactivities in mice. Conclusion: These results provided a basic for developing a new drug to treat patients with AD. * Keywords: Alzheimer's disease; Willughbela cochinchinessis; Scopolamin; Locomotor behaviors; Mice. INTRODUCTION Alzheimer’s deasease is one form of dementia in older humans. Mechanism of this kind disease has been suggested to be involved in neurodegeneration and formation of plaques and neurofibrillary tangles [1]. These changes in the brain cause behavioral disorders such as cognitive and memory impairments and locomotor hyperactivities. In patients with AD, it has been shown that patients with AD expressed hyperactivities in the late afternoon and the evening. These hyperactivities are termed as sundown syndrome or sundowing [2, 3]. In animal models of AD, previous studies have been demonstrated that animals .