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Survey on antibacterial activity of acrylate – styrene copolymer containing quaternary nitrogen atoms

In this research acrylate – styrene copolymer containing quaternary nitrogen atoms was synthesized by a bulk copolymerization method according to free radical mechanism. Antibacterial activity of this resin was examined by changing parameter values such as: types and amount of the neutralized agents, temperature of the neutralization reaction, etc. The antibacterial properties of the acrylate – styrene copolymer were evaluated via the agar diffusion test. | Journal of Science and Technology 55 (1B) (2017) 122–128 SURVEY ON ANTIBACTERIAL ACTIVITY OF ACRYLATE – STYRENE COPOLYMER CONTAINING QUATERNARY NITROGEN ATOMS Nguyen Vo Dang Canh*, Phan Quoc Phu Faculty of Materials Technology, HCMUT–VNUHCM 268 Ly Thuong Kiet Street, Ward 14, District 10, Ho Chi Minh City, Vietnam * Email: nguyenvodangcanh@gmail.com Received: 30 December 2016; Accepted for publication: 3 March 2017 ABSTRACT In this research acrylate – styrene copolymer containing quaternary nitrogen atoms was synthesized by a bulk copolymerization method according to free radical mechanism. Antibacterial activity of this resin was examined by changing parameter values such as: types and amount of the neutralized agents, temperature of the neutralization reaction, etc. The antibacterial properties of the acrylate – styrene copolymer were evaluated via the agar diffusion test. In addition, the molecular structure of the copolymer was performed in Fourier transformation infrared (FTIR) spectroscopy. Besides that, the hydrogels from the acrylate – styrene copolymer were also examined on their antibacterial properties. As results, the copolymer showed the highest antibacterial activities with the ratio of ammonia to acrylic acid about 0.8:1 and the neutralizing temperatures at 60 °C. Keywords: acrylate – styrene copolymer, quaternary nitrogen atoms, antibacterial. 1. INTRODUCTION The rise of the modern industrial revolution has led to the habitat degradation. The suitable climatic would create an appropriate environment for allowing the bacteria to live and grow that cause the risk of a pandemics, such as cholera, malaria, typhoid and so on. Besides, the evolutionary process of the biota has contributed to the bacteria that are resistant to increasing global threats to human life. Therefore, further study on antimicrobial resistance to protect the health has been focusing worldwide [1]. Besides focusing on studying improvement of antibiotics, research and .