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Ebook Computational biophysics of the skin: Part 2

(BQ) Part 2 book “Computational biophysics of the skin” has contents: Cellular scale modelling of the skin barrier, molecular scale modeling of human skin permeation, accessing the molecular organization of the stratum corneum using high-resolution electron microscopy and computer simulation, and other contents. | Chapter 8 Cellular Scale Modelling of the Skin Barrier Arne Nägel, Michael Heisig, Dirk Feuchter, Martin Scherer, and Gabriel Wittum Frankfurt University, Goethe Center for Scientific Computing, Kettenhofweg 139, 60325 Frankfurt am Main, Germany wittum@gcsc.uni-frankfurt.de Computational modelling and simulation of penetration processes in the skin barrier on multiple biological scales in space and time is increasingly being recognized as a powerful tool to develop and to refine hypotheses, focus experiments, and enable more accurate predictions. One area of the ongoing research effort is physiologybased transport models. On the one hand, these are based on first principles and describe processes in the skin mathematically in terms of conservation equations. On the other hand, these models employ detailed morphology information and are thus capable of exploiting relationships between form and function. Particularly, such models provide an understanding how microscopic physiological structure and heterogeneity govern penetration. In this chapter, we describe microscopic geometry models of the skin cells (e.g. corneocytes) and the lipid bilayers of the stratum corneum (SC). Computational Biophysics of the Skin Edited by Bernard Querleux Copyright © 2014 Pan Stanford Publishing Pte. Ltd. ISBN  978-981-4463-84-3 (Hardcover),  978-981-4463-85-0 (eBook) www.panstanford.com 218 Cellular Scale Modelling of the Skin Barrier The particular focus is on geometries based on tetrakaidekahedra (TKD). These polyhedra with 14 faces have certain desirable features for the generic construction of cellular membranes. We provide a detailed geometric description of these membranes, which is complemented by examples of computations in the simulation system UG. 8.1  Introduction The stratum corneum (SC) (see Fig. 8.1a) is the outermost skin layer of the epidermis of mammals. It consists of corneocytes and a lipid matrix. The corneocytes are dead, keratinized, fully .